The industrial establishments found in San Mateo are classified as light to medium industries. Welding shops and motor pool are among the predominant industries found within the municipality. Other industrial establishments are relatively small scale, like leather craft and kiskisan. Moreover, agri-business establishments which include poultry and piggery do exist within the municipality.

Various products are being manufactured in San Mateo. In fact, a group of different factories is found along Kambal Road, Barangay Guitnang Bayan 2. This includes San Mateo Rubber Corp. (Nikon and Durawalk Slippers), Jolly Food Corp., First Win Corp. (Slippers), and Golden Union Footwear Inc. (Evans Shoes). A Coca-Cola warehouse is also situated at Patiis Road corner GSIS Street (Daang Tubo) in Barangay Dulong Bayan 2. San Mateo also primarily manufactures gravel and sand aggregates together with other construction supplies that are found in hardwares distributed all over the municipality.

Commerce and Trade
The Central Business District is strategically located amidst the concentration of settlements. A major commercial area starts from the vicinity of the public market, bounded by the national road going to Rodriguez (Montalban) and Street of Daang Bakal in Barangay Guitnang Bayan 2. This commercial zone is a conglomeration of financial institutions, a public market, restaurants/small eateries, retail stores and the like.

Another area, which may be considered as major commercial area, is within the vicinity of De los Santos Street corner Gen. Luna Avenue, in Barangay Ampid 1. Other commercial areas extending to St. Mattheus Medical Hospital near the boundary of San Mateo and Marikina City are located near Puregold San Mateo (formerly the Producer’s Market) at Barangay Banaba and another at the corner of Patiis Road and Gen. Luna Avenue, in Barangay Malanday.

SM City San Mateo along Gen. Luna Avenue in Brgy. Ampid 1 adds to the list of major commercial centers of San Mateo. This SM Supermall and the very first full-service mall of San Mateo opens on May 15, 2015 serving local residents and from neighboring areas. Further boost in San Mateo’s economy is expected with the mall.

San Mateo has many bank branches like Banco de Oro (BDO), Bank of the Philippine Islands, Metrobank, Philippine Savings Bank (PSBank), EastWest Bank, China Bank, Philippine National Bank (PNB), Premiere Bank, Merchants Bank, Banco San Juan, Marikina Valley-San Mateo (MVSM) Bank, RCBC Savings Bank, United Coconut Planters Bank (UCPB), Banco Rodriguez, Country Builders Bank, the Real Bank (a thrift bank). Many automated teller machines in San Mateo are provided with security system such as anti-crime alarms. Security guards are also monitoring the premises of the banks in San Mateo for the safety of the customers.